REAGENTS AND METHODS USEFUL FOR DETECTINGS DISEASE

专利名称：REAGENTS AND METHODS USEFUL FOR

DETECTINGS DISEASES OF THE LUNG

发明人：PATRICIA BILLING-MEDEL,MAURICE

COHEN,TRACEY L. COLPITTS,PAULA N.FRIEDMAN,MICHAEL R. KLASS,JOHN C.RUSSELL,STEPHEN STROUPE

申请号：US09092296申请日：19980605

公开号：US20020188114A1公开日：20021212

摘要：A set of contiguous and partially overlapping cDNA sequences and

polypeptides encoded thereby, designated as LS147 and transcribed from lung tissue, isdescribed. These sequences are useful for the detecting, diagnosing, staging, monitoring,prognosticating, in vivo imaging, preventing or treating, or determining the predispositionof an individual to diseases and conditions of the lung, such as lung cancer. Also providedare antibodies which specifically bind to LS147-encoded polypeptide or protein, andagonists or inhibitors which prevent action of the tissue-specific LS147 polypeptide, whichmolecules are useful for the therapeutic treatment of lung diseases, tumors ormetastases.

申请人：BILLING-MEDEL PATRICIA,COHEN MAURICE,COLPITTS TRACEY L.,FRIEDMANPAULA N.,KLASS MICHAEL R.,RUSSELL JOHN C.,STROUPE STEPHEN

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