Ozkan B.;Bereket A.;Turan S.;Keskin S.;李开
【期刊名称】《世界核心医学期刊文摘：儿科学分册》 【年(卷),期】2005(000)009
【摘 要】To investigate the efficacy and tolerability of orlistat in obese adolescents, a prospective, open-label, randomised, controlled pilot trial was performed. A total of 22 adolescents with exogeneous obesity were started on orlistat (120 mg tid) and a daily multivitamin preparation in addition to conventional treatment which included nutritional and lifestyle modification programmes. The control group consisted of 20 obese adolescents who had similar duration of follow-up under conventional treatment alone. Of the 22 patients, 7 dropped out within the 1st month of the trial due to side-effects attributable to orlistat. The remaining 15 patients on orlistat were followed for 5-15months (average duration of treatment 11. 7 ± 3. 7 months). The control group was similar in age, sex, and duration of follow-up (10. 2 ± 3. 7months, range 6-17 months) to the orlistat group. Compared to initial body weight, patients in the orlistat group lost-6. 27 ± 5. 4 kg, whereas those in the control group gained 4. 16 ± 6. 45 kg (P < 0. 001) during the study period. Patients in the orlistat group lost-7. 65% ± 6. 5% of their initial body weight, whereas, those of the control group gained 5. 7% ± 8. 3% (P < 0. 001). The body mass index decreased in the orlistat group by-4. 09 ± 2. 9 kg/m2 while it increased by
+ 0. 11 ± 2. 49 kg/m2 in the control group (P < 0. 001). Mild gastrointestinal complaints (frequent stools) were experienced by all patients in the orlistat group. Conclusion: Orlistat could be a useful adjunct in the treatment of severe obesity in adolescents; however, gastrointestinal side effects limit its usefulness in almost one in three adolescents. 【总页数】2页(P32-33)
【作 者】Ozkan B.;Bereket A.;Turan S.;Keskin S.;李开
【作者单位】Bozkir Sokak No: 4/7 81030 Selamicesme-Istanbul Turkey 【正文语种】中 文 【中图分类】R589.2 【相关文献】
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