METHODS OF TREATING MENTAL DISEASES, INFLAMMATION

专利名称：METHODS OF TREATING MENTAL DISEASES,

INFLAMMATION AND PAIN

发明人：PIOMELLI, Daniele,BELTRAMO, Massimiliano申请号：EP97949723.7申请日：19971125公开号：EP09303B1公开日：20110921

摘要：Methods are disclosed for treating or preventing disorders such as mentaldiseases, inflammation and pain by inhibiting the enzyme anandamide amidohydrolase. Atherapeutically effective level of an anandamide amidohydrolase inhibitor is administeredsuch as a therapeutically effective level of a haloenol lactone. Preferably, the haloenollactone is of formula (I) wherein R is hydrogen, R1 is a halogen, and R2 is selected fromthe group consisting of aryl, aryloxy, and heteroaryl radicals, derivatives of said haloenollactones, and mixtures thereof. The haloenol lactone, E-6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyrane-2-one, is most preferred.

申请人：NEUROSCIENCES RES FOUND

地址：US

国籍：US

代理机构：Baker, Colin John

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