Method of pre-inducing a state of immune tolerance

专利名称：Method of pre-inducing a state of immune

tolerance before organ transplantation

发明人：Joel F. Habener,Henryk Zulewski,Elizabeth J.

Abraham,Mario Vallejo,Denise L.Faustman,Melissa K. Thomas

申请号：US101361申请日：20020502公开号：US06923959B2公开日：20050802

摘要：Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells thatare capable of differentiation into a variety of pancreatic islet cells, including insulin-producing beta cells, as well as hepatocytes. Nestin has been identified as a molecularmarker for pancreatic stem cells, while cytokeratin-19 serves as a marker for a distinctclass of islet ductal cells. Methods are described whereby nestin-positive stem cells canbe isolated from pancreatic islets and cultured to obtain further stem cells or pseudo-islet like structures. Methods for ex vivo differentiation of the pancreatic stem cells aredisclosed. Methods are described whereby pancreatic stem cells can be isolated,expanded, and transplanted into a patient in need thereof, either allogeneically,isogeneically or xenogenically, to provide replacement for lost or damaged insulin-secreting cells or other cells.

申请人：Joel F. Habener,Henryk Zulewski,Elizabeth J. Abraham,Mario Vallejo,Denise L.Faustman,Melissa K. Thomas

地址：Newton Centre MA US,Basel CH,Quincy MA US,Madrid ES,Weston MA US,BostonMA US

国籍：US,CH,US,ES,US,US

代理机构：Palmer & Dodge LLP

代理人：Kathleen M. Williams,Elizabeth S. Spar

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