ALPHA-AMYLASE ACTIVITY INHIBITORS

专利名称：ALPHA-AMYLASE ACTIVITY INHIBITORS发明人：MAKINO, Takashi c/o Kabushiki Kaisha

Yakult Honsha,AIYAMA, Ritsuo c/o KabushikiKaisha Yakult Honsha,DEGUCHI, Yoriko c/oKabushiki Kaisha Yakult Honsha,WATANUKI,Masaaki Kabushiki Kaisha YakultHonsha,NAKAZAWA, Masako KabushikiKaisha Yakult Honsha,MIZUKOSHI, HarumiKabushiki Kaisha Yakult Honsha,NAGAOKA,Masato C/O Kabushiki Kaisha Yakult

Honsha,HARADA, Katsuhisa Kabushiki KaishaYakult Honsha,OSADA, Kuniko c/o KabushikiKaisha Yakult Honsha

申请号：EP01912225.8申请日：20010309公开号：EP12623B1公开日：20121024

摘要：The present invention relates to an α-amylase activity inhibitor containing, as aneffective component, polyphenols obtained through the following process: guava leavesand/or guava fruit are subjected to extraction with one or more solvents selected fromamong water and hydrophilic solvents; the resultant extract is subjected to ultrafiltration,to thereby remove substances having a molecular weight of less than 5,000; theremaining fraction is subjected to the butyl support hydrophobic chromatography. The

elution (flow rate: 1 mL/min) of the sample was accomplished with the pH gradient by useof sodium dihydrogenphosphate and sodium phosphate solution (0.02 mol/L) and afraction of the eluted substance is recovered, which fraction corresponds to the thirdsingle peak of an elution curve which is obtained when the absorbance of the substance ismeasured at 260 nm. The present invention also relates to an α-amylase activity inhibitorcontaining, as an effective component, polyphenols having specific physicochemicalproperties, and to food and beverages containing the α-amylase activity inhibitor. The α-amylase activity inhibitor of the present invention exhibits remarkably excellent α-amylase inhibitory activity as compared with guava extract. Accordingly, food andbeverages containing the α-amylase activity inhibitor are diet food and beveragessuitable for people of high blood-sugar level or hyderlipidemia.

申请人：YAKULT HONSHA KK

地址：JP

国籍：JP

代理机构：Hartz, Nikolai

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