(AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL

专利名称：(AZA)INDOLE DERIVATIVE AND USE

THEREOF FOR MEDICAL PURPOSES

发明人：SHIMIZU, Kazuo,TAKIGAWA,

Yasushi,FUJIKURA,

Hideki,IIZUKA,Masato,HIRATOCHI,Masahiro,KIKUCHI, Norihiko

申请号：EP08740190.7申请日：20080410公开号：EP2133332A1公开日：20091216

摘要：The present invention provides compounds useful as agents for the preventionor treatment of a disease associated with abnormal serum uric acid level which has auricosuric activity or the like. The present invention relates to (aza)indole derivativesrepresented by the following general formula (I) having xanthine oxidase inhibitoryactivities and useful as agents for the prevention or treatment of a disease associatedwith abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In theformula (I), T represents nitro or cyano and the like; ring J represents aryl or heteroaryland the like; Q represents carboxy or 5-tetazolyl and the like; Y represents H, OH, NH,halogen, nitro, alkyl, alkoxy and the like; X, X and X independently represent CR or N; Rand R independently represent halogen, cyano, haloalkyl, A-D-E-G, -N(-D-E-G) and thelike, in the formula, A represents a single bond, O, S and the like; D and G independentlyrepresent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene,heteroarylene and the like; E represents a single bond, O, S, COO, SO and the like.

申请人：Kissei Pharmaceutical Co., Ltd.

地址：19-48, Yoshino Matsumoto-shi Nagano 399-8710 JP

国籍：JP

代理机构：Behnisch, Werner

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