Assessment of sleep quality and sleep disordered b

专利名称：Assessment of sleep quality and sleep

disordered breathing based oncardiopulmonary coupling

发明人：Joseph E. Mietus,Chung-Kang Peng,Robert J.

Thomas,Ary L. Goldberger

申请号：US111790申请日：20050712

公开号：US20050267362A1公开日：20051201

专利附图：

摘要：An assessment of sleep quality and sleep disordered breathing is determined

from cardiopulmonary coupling between two physiological data series. An R-R intervalseries is derived from an electrocardiogram (ECG) signal. The normal beats from the R-Rinterval series are extracted to produce a normal-to-normal interval series. Theamplitude variations in the QRS complex are used to extract a surrogate respirationsignal (i.e., ECG-derived respiration) associated with the NN interval series. The two seriesare corrected to remove outliers, and resampled. The cross-spectral power andcoherence of the two resampled signals are calculated over a plurality of coherencewindows. For each coherence window, the product of the coherence and cross-spectralpower is used to calculate coherent cross-power. Using the appropriate thresholds forthe coherent cross-power, the proportion of sleep spent in CAP, non-CAP, and wakeand/or REM are determined. Coherent cross-power can be applied to differentiateobstructive from non-obstructive disease, and admixtures of the same.

申请人：Joseph E. Mietus,Chung-Kang Peng,Robert J. Thomas,Ary L. Goldberger

地址：Cambridge MA US,Sharon MA US,Newton MA US,Newton Centre MA US

国籍：US,US,US,US

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