CONSTRUCTION AND CHARACTERIZATION OF MULTIMERIC IL

专利名称：CONSTRUCTION AND CHARACTERIZATION

OF MULTIMERIC IL-15-BASED MOLECULESWITH CD3 BINDING DOMAINS

发明人：LIU, Bai,RHODE, Peter,WONG, Hing, C.申请号：EP17803651.3申请日：20170526公开号：EP34352A1公开日：20190410

摘要：The invention features soluble fusion protein complexes comprising at leasttwo soluble fusion proteins. For example, the first fusion protein is an anti-CD3 antibodycovalently linked to an interleukin-15 (IL-15) polypeptide or functional fragment thereof.The second fusion protein comprises a binding domain that recognizes disease antigens,wherein this domain is covalently linked to a soluble interleukin-15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. One or both of the first and secondfusion proteins further includes an immunoglobulin Fc domain or a functional fragmentthereof, and the IL-15 domain of first fusion protein binds to the soluble IL-15Rα domainof the second fusion protein to form a soluble fusion protein complex. The inventionfurther provides methods for making and using the complexes of the invention.

申请人：Altor BioScience Corporation

地址：2810 North Commerce Parkway Miramar, Florida 33025 US

国籍：US

代理机构：Forstmeyer, Dietmar

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